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AZ 3146

CAS No. 1124329-14-1

AZ 3146( AZ3146 | AZ 3146 | AZ-3146 )

Catalog No. M17147 CAS No. 1124329-14-1

AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AZ 3146
  • Note
    Research use only, not for human use.
  • Brief Description
    AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM.
  • Description
    AZ3146 is a novel and potent Mps1 inhibitor, which was used to probe the role of Mps1's catalytic activity during mitosis. AZ3146 also inhibits FAK, JNK1, JNK2, KSP and Kit. In in vitro kinase assays, AZ3146 inhibited human Mps1Cat with an IC50 (50% inhibitory concentration) of ~35 nM. AZ3146 also efficiently inhibited autophosphorylation of full-length Mps1 immunoprecipitated from human cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    AZ3146 | AZ 3146 | AZ-3146
  • Pathway
    Microbiology/Virology
  • Target
    HSV
  • Recptor
    Mps1
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1124329-14-1
  • Formula Weight
    452.55
  • Molecular Formula
    C24H32N6O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 11.75 mg/mL 25.96 mM;
  • SMILES
    COc1c(Nc2ncc3n(C)c(=O)n(C4CCCC4)c3n2)ccc(OC2CCN(C)CC2)c1
  • Chemical Name
    9-cyclopentyl-2-(2-methoxy-4-(1-methylpiperidin-4-yloxy)phenylamino)-7-methyl-7H-purin-8(9H)-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hewitt L, et al. J Cell Biol, 2010, 190(1), 25-34.
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